By Dr. Dimitar Marinov

medical reviewed by Best HGH Doctors and Clinics dedicated team.

Evidence basedThis article is reviewed by medical professionals for the relevancy and accuracy of the content. Every article is evidence-based and contains references to peer-reviewed studies and academic research.

Do you suffer from chronic fatigue? If your daily energy has suddenly declined and your home or work productivity is suffering, those might be signs of growth hormone deficiency (GHD). Patients with chronic fatigue syndrome have significantly lower growth hormone and insulin growth factor-1 (IGF-1) levels when compared to healthy controls.

GHD can lead to lack of energy, fatigue, tiredness, and lower tolerance to mental and physical work

Furthermore, GHD can also reduce your motivation and capability to perform physical tasks. One study in 35 individuals investigated the impact of GHD on aerobic activity. Oxygen consumption was significantly lower in the GHD group which led to reduced physical abilities and lack of energy.

Lack of motivation, energy and chronic fatigue

The perception of increased fatigue and impaired physical performance in patients with GHD is caused by limited oxygen delivery to the muscles during work or physical activities. GHD can reduce your energy capacity for otherwise normal daily activities.

These symptoms can have a negative impact on your quality of life and hurt your confidence, motivation, and productivity at home or work. In most cases, the reason for chronic fatigue remains unknown. Apart from GHD, possible underlying causes include different chronic infections, medication therapies, or mental health problems.

How HGH affects motivation and energy levels

HGH has a direct impact on your energy state and vitality. The hormone can give you energy by mobilizing fat from the adipose tissues around your belly. The energy released into your bloodstream can be used for physical activity, muscle growth, and tissue repair.

Furthermore, HGH supports the normal oxygen consumption of your tissues. This way it helps your body maintain optimal levels of energy and productivity during daily physical tasks. HGH also improves your mood which further increases motivation and work capacity.

If GHD is left untreated, it can seriously impact your energy levels and overall well-being. A study in 85 GHD patients revealed that those left untreated suffered from fatigue and progressive deterioration in physical mobility. In comparison, those treated properly had significant improvement in both energy levels and vitality.

How to treat energy loss due to GHD

Long-term HGH therapy can improve energy levels and subjective well-being in GHD patients. Six months of HGH therapy in GHD adults can improve physical capacity and boost energy levels for daily physical tasks. According to the researchers, these effects also significantly improve the quality of life in GHD patients.

Conditions such as fibromyalgia where fatigue is the primary symptom might also be related to insufficient levels of HGH. A study in 50 women revealed that HGH therapy leads to a significant reduction in fatigue and improvement in the patient’s quality of life and energy capacity.

Chronic fatigue and lack of energy or motivation can also affect your mood and mental performance. In fact, people with GHD can experience anxiety, depression, and even social phobia.

Discover more about the mental health problems related to GHD


Mental health problems


GHD in adults can lead to various problems with memory, attention and cognitive performance. Also, lead to increased levels of anxiety, severe depression, and even social isolation

Find out more