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HGH Injections

HGH injections can result in a significant increase in your serum growth hormone levels and promote a range of benefits. Especially for people suffering from growth hormone deficiency (GHD) and experiencing various symptoms of low GH levels
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Improve abdominal fat loss

Increase muscle mass

Better energy levels and quality of life

  • What is HGH?

    HGH, also known as somatropin, is a medication that was created to have the same 191 amino acid structure as the naturally occurring growth hormone (somatotropin) that is normally produced in humans by the pituitary gland.

    It was first developed in 1981 by an American biotechnology company called Genentech via recombinant DNA technology. The technology allows for an exact replication of the sequence of the native growth hormone.

    Thus, the HGH used as a medication is also commonly termed recombinant HGH (rhGH). Recombinant HGH was primarily developed for the management of conditions related to growth failure in children, such as GHD.

    In addition, HGH therapy can also be used for the management of GHD symptoms in adults. Although the process of growth is completed in adulthood, the synthesis of GH is important for regulating various metabolic processes.

    Thus, GHD is associated with specific symptoms in adults, such as abdominal obesity, muscle loss, and fatigue. The condition may also increase the risk of osteoporosis, cardiovascular problems and other chronic diseases.

    Consequently, HGH therapy was studied extensively for potential benefits and safety in the treatment of GHD. It was found to effectively increase serum growth hormone levels and consequently address all of the symptoms that may occur due to GHD.

    In 1985, HGH therapy was officially approved by the U.S. Food and Drug Administration (FDA) for the management of stunted growth in children.
    As of 2024, the list of FDA-approved indications for HGH therapy includes growth failure due to GHD, genetic syndromes, short bowel syndrome (SBS), chronic renal insufficiency and more.

    The FDA also approved HGH for adults suffering from GHD or SBS. The medication is also authorized for short-term therapy in patients with AIDS/HIV-related muscle wasting.

    In the US, HGH is approved under several brands including:

    • Humatrope
    • Norditropin
    • Saizen
    • Genotropin
    • Omnitrope
    • Zomacton


    While HGH is not available as a generic medication, you may obtain one of these brands of HGH if you have a medical prescription. All of these medications contain recombinant HGH.

    As a prescription-only medication, HGH cannot be legally obtained over the counter or used without a medical prescription.

  • How Does HGH Work?

    HGH works only when administered via an injection as this is the only reliable way that the medication can increase your serum GH levels.

    Unfortunately, HGH cannot be effectively administered orally or transdermally, as the amino-acid structure of the hormone breaks down easily in the digestive system, and cannot pass through the natural barriers of the skin.

    The most convenient and reliable way to inject HGH is via subcutaneous injections, as it is relatively easy to self-administer and leads to a prolonged effect.

    When injected, subcutaneous HGH injections lead to peak serum GH concentrations within 4-5 hours, and the levels remain over the baseline for about 14-18 hours in total.

    The elevated GH levels exert several beneficial effects including increased fat mobilization and higher synthesis of anabolic mediators such as insulin-like growth factor 1 (IGF-1):

    • HGH works by stimulating the activity of the hormone-sensitive lipase (HSL) in fat tissue, which helps your body mobilize fat for burning. Moreover, HGH also interacts with other enzymes, ultimately blocking the uptake of mobilized fatty acids back into the fat cells. GH also appears to have stronger effects on certain fat depots, especially the unhealthy visceral fat that accumulates around the abdomen and internal organs.
    • HGH stimulates the synthesis of IGF-1 which is the main anabolic mediator of the hormone. IGF-1 can stimulate muscle protein synthesis while at the same time slowing down muscle protein breakdown. This results in a net increase in muscle growth, especially in individuals who were otherwise experiencing muscle loss.
    • Via IGF-1, HGH may also stimulate collagen synthesis which is highly beneficial for a wide range of tissues and organs. Notably, increased collagen production helps increase skin thickness. Moreover, collagen is also one of the main structural components in bones. IGF-1 can also stimulate the activity of osteoblasts (bone cells that form new bone tissue) therefore benefiting bone density.


    To ensure that HGH works for you, it is also essential to receive medical therapy from an experienced physician, who will carefully oversee the whole treatment process.

    In our clinic, we offer HGH therapy under the control of seasoned medical specialists, who follow strict treatment protocols. This guarantees the safety and effectiveness of the therapeutic process.

  • Benefits of HGH

    One of the main and most sought-after benefits of HGH is the reduction of abdominal fat which helps lower the risk of chronic diseases, especially in patients with GHD.

    In addition, the medication can also improve your quality of life and energy levels, reduce cardiovascular risk factors such as cholesterol levels and may potentially increase your lean body mass.

    Here is a more detailed overview of the benefits you may expect, as shown by the latest scientific evidence:

    • Fat loss: A 2011 systematic review of several trials conducted in adults with GHD reported that HGH therapy for 6-12 months led to significant fat loss in the majority of trials, amounting to a total of 7-10% fat mass reduction from baseline, especially abdominal fat loss. Consequently, there was also a -1.2 inch mean decrease in waist circumference. Healthy adults also report about -4.63 lbs reduction in body fat following a mean HGH therapy duration of 27 weeks.
    • Lean mass gains: The aforementioned reviews also report about 2-5% increase in lean muscle mass in GHD patients, and about a mean +4.63 lbs increase in lean mass in healthy individuals following 6-7 months of HGH therapy.
    • Reduced cholesterol levels: HGH treatment led to a reduction in total cholesterol levels by 4-8% and low-density lipoprotein (LDL) cholesterol levels by 11-16%. HGH injections were also noted to cause a significant reduction in total cholesterol levels in healthy volunteers.
    • Improved quality of life: GHD patients also experienced significant improvement in their quality of life following 6-12 months of HGH therapy, and this was consistently observed amongst all 11 trials included in the aforementioned 2011 systematic review.

  • Side Effects of HGH

    Since 1981, there have been numerous trials that have confirmed the safety and tolerability of HGH therapy in various medical conditions, as well as in healthy volunteers.

    One of the largest summaries of such trials is a 2007 systematic review of 31 randomized clinical trials that evaluated the safety of HGH in healthy older adults.

    According to the data, HGH appears safe and well tolerated, with the majority of adverse events being related to the water retention that typically occurs during HGH therapy. The water retention manifested with:

    • Edema of the limbs (affected 50% of participants)
    • Joint pain (21% of participants)
    • Carpal tunnel syndrome (19% of participants)


    These complaints are transient and can be largely avoided by starting HGH on a lower dose and then carefully titrating it up according to the individual responses.

    In addition, about 22% of the volunteers experienced a worsened glucose metabolism, which was related to the antagonistic effects between HGH and insulin, and the consequent increase in insulin resistance.

    Yet, further research suggests that this increase in insulin resistance is also transient, and insulin sensitivity typically returns to normal within a few months.

    With that being said, there are several contraindications against HGH therapy, as the medication may worsen the progression and prognosis of these conditions:

    • Active cancer (other than basal cell or squamous cell skin cancers) – HGH elevates IGF-1 levels and may speed up cellular proliferation, including the proliferation of cancer cells.
    • Acute critical illness – HGH has been observed to worsen the prognosis in critically ill patients.
    • Uncontrolled diabetes and diabetic retinopathy.

  • How to Use HGH

    The proper amount of HGH to inject will be determined by your physician who can use one of two primary dosing methods: weight-based or non-weight-based.

    The non-weight-based method is generally recommended for adults, due to its lower risk of adverse effects.

    This method starts with a standard daily dosage of 0.2 mg (equivalent to 0.6 IU/day). Depending on your response, your doctor may increase this using increments of 0.1-0.2 mg every 4-8 weeks.

    Alternatively, the weight-based method is derived from the patient’s body weight but it was originally designed for children and studies have shown that weight-based method poses a higher risk of overestimation and side effects in adults.

    Most patients find effective symptom management at dosages between 0.4 to 0.8 mg/day. The ideal dose within this range varies with age and gender.

    For example, premenopausal women might require higher doses due to the counteracting effect of estrogen, while older individuals should opt for lower doses as they are at an increased risk of side effects.

    Typically, FDA-approved HGH brands suggest a maximum of 1.2 mg/day. Such dosages allow for safe and effective therapy that can continue for prolonged periods of time, as stopping HGH injections usually results in the return of GHD symptoms.

    HGH is commonly injected daily, subcutaneously and the optimal timing depends on individual routines, though some studies indicate taking HGH before sleep works better for mimicking the natural function of the pituitary gland.

    Different brands of HGH are available as either auto-injection devices that are preloaded, premixed and ready for use, or as HGH vials that contain a lyophilized powder.

    Lyophilized HGH powder is a stable product with a long shelf life. Yet it must be reconstituted with a suitable solvent before use. The process is done manually using a sterile syringe and needle.

    It is recommended to use bacteriostatic water, as it contains 0.9 benzyl alcohol as a preservative. This is a safe solvent that extends the shelf-life of HGH.

    Once reconstituted with bacteriostatic water, HGH must be refrigerated at temperatures between 36-46ºF and has a shelf-life of about 28 days.

    Step-by-step guide on how to inject HGH

    If you are prescribed HGH, our medical doctors will show you all the steps of self-administering at home.

    After obtaining HGH (as a vial or an autoinjector), you will also need the following items:

    • Alcohol wipes/swabs
    • Sterile gauze
    • Bandages
    • Disposable container for sharp materials


    After HGH has been prepared for use, it’s essential to choose an appropriate injection area. The abdominal area is often the preferred site for self-injection due to its ease of access and less discomfort. Here’s a concise step-by-step guide for HGH injection procedure:

    1. Clean your hands thoroughly and sanitize them.
    2. Sterilize the vial’s stopper if using a prepared solution.
    3. Pick an injection site and clean it with an alcohol swab.
    4. For vial-based products, make sure you are using a sterile needle for subcutaneous injections and not one for reconstitution. Then draw the correct dose of HGH. For auto-injector devices, adjust the correct dose on the device.
    5. Gently grasp the skin with your non-dominant hand and insert the needle at a 45° angle with your dominant hand, ensuring the needle’s bevel faces up to minimize skin damage. If using an auto-injector device, attach a sterile needle and insert it at a 90° angle.
    6. Depress the button/stopper completely, holding the needle in place for a few seconds.
    7. After removing the needle, apply sterile gauze and a bandage without pressing or massaging the area.
    8. Safely dispose of the used needle and syringe in a sharps container.


    Always use new, sterile needles for subsequent injections and rotate the injection sites to prevent local damage to the subcutaneous fat tissue.

    Do not shake or tap the medication forcefully because it will be inactivated.

    Furthermore, make sure to store the HGH properly and avoid freezing, heating or direct sunlight.


How Long Does HGH Stay In Your System?

Studies suggest that HGH injections administered subcutaneous have a half-life of 3-4 hours. Considering that most medications stay in the human organism for 4-5 half-lives, it may be safe to assume that HGH will stay in your system for about 20+ hours following and injection.

What Happens When You Stop Taking HGH?

HGH therapy is not associated with physical or psychological dependance. The medication does not affect the function of the pituitary gland and serum GH levels will return to normal when you stop taking HGH.

Does HGH Affect Other Hormones?

HGH has not been reported to affect other hormones directly, except for insulin due to its antagonistic effects. Yet, long-term HGH may have beneficial effects for the natural production of hormones like testosterone in men due to its fat-burning effect on abdominal fats.


"Once I started using HGH under careful medical supervision, I've noticed a remarkable reduction in abdominal fat. The guidance of experienced specialists made the process both effective and safe, giving me peace of mind. I feel rejuvenated and more confident in my body."


Verified review