By Dr. Dimitar Marinov

medical reviewed by Best HGH Doctors and Clinics dedicated team.

Evidence basedThis article is reviewed by medical professionals for the relevancy and accuracy of the content. Every article is evidence-based and contains references to peer-reviewed studies and academic research.

The human growth hormone (HGH) is a peptide that’s often rumored as the key to reversing aging and retaining a youthful appearance.

Therefore, many companies exploit the desire to look and feel younger by offering over-the-counter solutions to the problem that HGH levels drop as you age.

One of the most popular dietary supplements that supposedly boost your natural HGH production and reverses aging is SeroVital.

According to the manufacturer’s claims, the product has multiple benefits and is backed by scientific evidence. Yet, once you take a deeper look you may notice some concerning issues.

Ultimately, the product may turn out to be just a waste of money if you are healthy, but the consequences may be more dramatic if taken instead of therapy by someone with a medical condition.

In this article, we will break down the available scientific evidence on SeroVital and give you the facts behind all the marketing claims.

What Serovital is claimed to be?

SeroVital is a supplement that, according to the claims, can reverse aging by supporting the body’s natural production of HGH. The product is developed by Sierra Research Group and marketed by SanMedica International.

There are 3 main dietary supplement specifications: SeroVital Renewal Complex for women (capsules), SeroVital Advanced for women (capsules), and SeroVital Rapid Dissolve Powder.

All of these products share similar claims, such as:

  • boosting your HGH levels
  • exerting anti-aging effects
  • increasing lean muscle mass
  • reducing skin wrinkles and fine lines
  • increasing energy levels
  • improving sleep quality
  • supporting immunity
  • causing fat cells to shrink


As mentioned on the official website, these claims are not evaluated by federal regulatory agencies.

Indeed, dietary supplements are not a subject of control by the FDA so the safety and effectiveness of such products are largely unknown. Currently, the only FDA-registered product with the name SeroVital is a hand sanitizer.

According to the official SeroVital website, the claims are presented as “beliefs of experts” regarding the benefits of higher HGH levels.

Yet, this contradicts the current scientific consensus by experts and researchers that increasing HGH is not an effective anti-aging strategy.

The only benefits observed in healthy individuals include improved body composition, and that is when using a reliable method to increase growth hormone levels, such as HGH injections.

Besides, some authors even suggest that increasing HGH in healthy older individuals may promote aging rather than slow it down.

Does SeroVital really work?

SeroVital does not contain HGH and thus it can’t help patients with growth hormone deficiency (GHD). GHD is a condition caused by the inability of the pituitary gland to produce sufficient GH levels.

Does SeroVital supplements work?

Therefore, stimulating natural HGH production is an ineffective method to manage the symptoms caused by low growth hormone levels in these patients.

The symptoms of GHD can be managed only via the application of exogenous growth hormone. The hormone must be injected in order to successfully raise serum GH levels.

Growth hormone is a peptide that gets destroyed in the digestive system if taken orally. Thus, pills or other oral formulations are not effective for managing GHD.

On the other hand, the official website of SeroVital states that its benefits for healthy people are clinically and scientifically validated.

Yet, there is only one full text available on the effects of SeroVital. The study was a randomized controlled trial, funded by Sierra Research Group – SeroVital’s developer.

The study involved only 16 participants, the majority of whom (75%) were men, despite the fact that the product is marketed mainly toward women. The researchers in the trial reported a short-term 682% increase in HGH levels, 2 hours after ingestion.

The increase from SeroVital supplement won’t last more than 2-3 hours

Does SeroVital work for women the same way it works for men?

It is unclear what the minimum or maximum effects are achieved or what is the difference between males and females, considering women are significantly less sensitive to HGH stimulation.

Furthermore, the funding is often received only when the results are submitted and approved by the funder. Therefore, research sponsorship is always associated with a significant risk of bias.

There is also an abstract reporting on SeroVital’s effects on patients with fibromyalgia. Yet, the full text is unavailable and the trial is again biased because it was led by one of SeroVital’s experts that publicly endorses the supplement.

Due to the small number of studies, low sample size, and high risk of bias, we can conclude that the clinical evidence cited on the website is of poor quality.

If you’re looking for simple and natural ways to increase GH levels, you can use these scientifically proven methods that will definitely help you boost your GH levels.

What is the opinion of the Court?

Because of the widespread marketing and poorly supported claims, there have been several lawsuits against Sierra Research Group and SanMedica International.

The main complaints in these lawsuits include lack of scientific evidence, false advertising, and violation of several consumer acts and laws.

The accusers also state that they did not receive any of the advertised benefits of SeroVital and “in no way, shape or form looked or felt younger” even though they used the product as directed.

How effective and safe are SeroVital’s ingredients?

SeroVital contains amino acids that may exert a short-lived stimulus on HGH production in healthy individuals.

How effective are SeroVital ingredients?

For example, two of the amino acids in SeroVital are lysine and arginine. They are common ingredients in HGH-boosting supplements but the evidence on their effectiveness is conflicting.

One study reported a 2-fold increase in the peak HGH production after arginine supplementation in 8 young active men.

Yet, several other studies investigating the combined effect of lysine and arginine report a lack of effectiveness in both younger and older men.

Another ingredient – glutamine, may also result in a slight HGH increase according to a small 26-year old study. Unfortunately, the results have not been replicated since.

Furthermore, the HGH-increasing effects after supplementation with these amino acids appear to be short-lived, if any at all.

Even if an 8-fold spike was possible after SeroVital supplementation it wouldn’t last more than 2-3 hours. Such a short-term increase in HGH is not likely to produce any notable health effects.

The rest of SeroVital’s ingredients include oxo-proline, fermented L-cysteine, and Schizonepeta (aerial parts) powder. There is not a single study suggesting any increase in HGH levels after supplementation with these ingredients.

What are the side effects of using SeroVital?

The majority of the information about the effects of Serovital comes from sponsored posts and PR publications that do not report any side effects at all. There are numerous reviews published on these affiliated sites and all appear to be nothing but positive.

But we have concluded that SeroVital may lead to side effects typical for the different amino acids in the product. And due to its ineffectiveness in raising GH levels, there are no adverse reactions associated with high levels of growth hormone, such as acromegaly. However, according to research, the side effects of the amino acids contained in SeroVital may include:

  • stomach pain
  • heartburn
  • nausea
  • vomiting
  • diarrhea
  • constipation
  • bloating
  • lightheadedness
  • low blood pressure
  • allergic reaction

How does marketing help in the promotion

One of the reasons for SeroVital’s popularity despite its questionable effectiveness is the aggressive marketing strategy of the company.

Public relations

It presents the product as a natural solution to low HGH which feeds into the misconception that Serovital is safer and more effective than synthetic HGH.

Yet, standard HGH therapy is well-studied, strictly regulated, and FDA-approved for use in both children and adults. Any adverse reactions are directly related to its main effect – increasing serum GH levels.

Serovital reviews from verified buyers

The reviews on Amazon appear to be more genuine and critical. Here are just 7 of all the comments about their best product – “SeroVital Advanced” on Amazon:

“I used this product for 30 days and noticed NO change in my skin or hair, my energy level was actually lower, and I experienced weight gain, not loss. This was a VERY expensive experiment and would not recommend” – Tstautz

“This stuff made me very sick, so I threw it away.” – Lynne

“I have been taking this product for three months. I take it as directed with no food besides water two hours prior and two hours after taking the supplements. I have seen no change in my skin my hair my mood my weight etc.” – Allyn

“I’m 63 years old and I purchased the regular SeroVital at my local Costco store. I took it religiously as directed for approximately 3 weeks. Within that amount of time, I started getting horrible body aches from my feet to shoulders plus severe fatigue. Prior to that I had the normal aches and pains a 63 years old woman would have, but nothing like what I experienced since taking the supplement. It’s 3 days since I stopped, and I’m still not back to “normal”. I’m hoping I didn’t trigger something else by taking this stuff.” – Carol

“After seeing the commercials on TV and in other advertisements, I was truly hoping this product would work. It didn’t, not even a little bit. To say I was disappointed doesn’t even begin to describe it.” – SCB

“I have taken this faithfully for a year, I’m 15 pounds heavier, my hair is course and has fallen out. The makers and advertisers of Serovital should be sued for all the lies they publish. As a medical professional I should of known better. Please don’t be lured in by the lies!” – Ramona

“After 3 days I was in pain arm shoulder wrist and indigestion. If you value your health don’t go near this. I read up some more on this and many reviews had the same complaints. I’m out 100 but I’ll be pain free and healthy!!!” – Kheak